- Title
- Host-microbiome interactions: the aryl hydrocarbon receptor and the central nervous system
- Creator
- Lee, Hae Ung; McPherson, Zachary E.; Tan, Bryan; Korecka, Agata; Pettersson, Sven
- Relation
- Journal of Molecular Medicine Vol. 95, Issue 1, p. 29-39
- Publisher Link
- http://dx.doi.org/10.1007/s00109-016-1486-0
- Publisher
- Springer
- Resource Type
- journal article
- Date
- 2017
- Description
- The microbiome located within a given host and its organs forms a holobiont, an intimate functional entity with evolutionarily designed interactions to support nutritional intake and reproduction. Thus, all organs in a holobiont respond to changes within the microbiome. The development and function of the central nervous system and its homeostatic mechanisms are no exception and are also subject to regulation by the gut microbiome. In order for the holobiont to function effectively, the microbiome and host must communicate. The aryl hydrocarbon receptor is an evolutionarily conserved receptor recognizing environmental compounds, including a number of ligands produced directly and indirectly by the microbiome. This review focuses on the microbiome-gut-brain axis in regard to the aryl hydrocarbon receptor signaling pathway and its impact on underlying mechanisms in neurodegeneration.
- Subject
- host-microbiome interactions; neurodevelopment; neurodegeneration; aryl hydrocarbon receptor
- Identifier
- http://hdl.handle.net/1959.13/1351902
- Identifier
- uon:30794
- Identifier
- ISSN:0946-2716
- Rights
- © The Author(s) 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
- Language
- eng
- Full Text
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